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These may affect a smaller group of patients: Although rare, some patients may experience: GLP-1 receptor agonists are contraindicated in individuals with: Its important to share your complete medical history with your doctor before starting treatmentespecially if you have existing gastrointestinal, gallbladder, or thyroid concerns

The injection volumes are larger, but the precision at lower doses improves significantly

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For a complete overview, our guide on semaglutide fatigue covers why tiredness happens and when it signals a problem versus a normal adaptation phase