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Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

On the other hand, in vitro studies have shown that -carotene decreases the oxidative stress by suppressing NADPH oxidase, resulting in low ROS levels, which, in turn, interrupts the activation of NF-kB and protects the TNF receptor-related factor (TRAF, TRAF1, and TRAF2) genotypes from nuclear translocation and nuclear transcriptional targets

Beutler LR, Chen Y, Ahn JS, Lin YC, Essner RA, Knight ZA