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Men in the study experienced greater anabolic benefits, including improvements in insulin sensitivity and quality of life markers
Burmeister MA, Ferre T, Ayala JE, King EM, Holt RM, Ayala JE
Beyond lipid metabolism, the GLP-1 RAs also shown critical anti-inflammatory and antioxidant effects, collectively positioning these GLP-1 RAs as a leading pharmacotherapy for MASLD (Pasta et al., 2025
Pharmacol Ther 240(1):108219 Scripture CD, Sparreboom A, Figg WD (2005) Modulation of cytochrome P450 activity: implications for cancer therapy
These effects are partially mediated through PCSK9 inhibition, since berberine reduces PCSK9 expression, which allows LDL receptors to be recycled more effectively rather than degraded
