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While co-treatment with 300 nM Ex-4 during differentiation suppressed osteogenic marker expression of RUNX2 , bone morphogenetic protein 2 ( BMP2 ), ALP and matrix deposition, early exposure prior to differentiation start or at the time of cell isolation, enhanced osteogenic marker expression [15]
(c) The final phase, Step III (Mineralization), was carried out by Streptomyces atratus strain ROA017 (D1)
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