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FDA said that the peptide is not adequately characterized and has the potential for peptide-related impurities due to incomplete coupling reactions, truncations, or side reactions

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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)

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