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Some patients achieve significant weight loss at 10mg weekly and experience unnecessary side effects at higher doses
Across the major trials, average weight loss rises with each receptor added: 13.7% for semaglutide, 20.2% for tirzepatide, and 28.3% for retatrutide
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These challenges stem from the large molecular size of the peptides, their suboptimal ionization efficiency in mass spectrometry, and inherent issues related to sensitivity and sample preparation
They are doing it not primarily for weight loss the effect that has made Ozempic a Hollywood staple and a reliable awards-show punchline but for the surprising and widely touted side benefits, particularly its anti-inflammatory properties
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