Clinical data from the SURMOUNT trials demonstrated that tirzepatide delivers weight reductions between 20-21% at the highest therapeutic dose, significantly outperforming older GLP-1-only treatments
However, in states of leptin resistance such as obesity, this regulatory mechanism may be impaired (102, 103)
Scarvie KM, Ballantyne AO, Trauner DA (1996) Visuomotor performance in children with infantile nephropathic cystinosis
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for T2DM, exert both metabolic and anti-inflammatory effects, which may offer therapeutic benefits for psoriatic disease, particularly in the early stages of PsA
How much water should I drink while on GLP-1 medications