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Both semaglutide and tirzepatide have half-lives of approximately 7 days, meaning the drug is engineered to maintain steady-state blood concentrations from week to week
N Engl J Med 385(16):14511461
These side effects are typically mild to moderate and are most common during the first few weeks of treatment or after a dose increase
Practical solutions include dressing in layers, keeping extremities warm, and ensuring caloric intake is not excessively low
However, diabetes itself predisposes individuals to neuropathy, potentially confounding the association between GLP-1 RAs and NAEs
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