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doi: 10.1074/jbc.270.45.26762 64 NicholKACouzensMHShineJHerzogHCunninghamAM
These benefits required dual GLP-1R/GLP-2R engagement, as PG-102 outperformed monospecific Fc fusion agonists or their combination and promoted coordinated receptor trafficking with delayed internalization
Of note, in people with advanced DKD, additional glucose-lowering beyond SGLT2 inhibition will be necessary, making GLP-1 receptor agonists valuable drugs in this population
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