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Semaglutide was not found to be mutagenic or clastogenic in a typical battery of genotoxicity tests or bacterial mutagenicity
placebo in patients with obesity regardless of diabetes status
Consistent with the multi-society guidance on GLP-1 receptor agonists, the new MIPS measure, ABG 45, specifically targets interventions for symptomatic gastric distension patients taking GLP-1 receptor agonists, as well as other high-risk gastric distension patients such as those with bowel obstruction, ileus, or incarcerated hernias
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