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Simultaneous quantification of these two oxidized metabolites by electrochemical HPLC assay demonstrated that human P450 2E1 selectively oxidizes APAP to NAPQI (determined as glutathione conjugate, GS-APAP), whereas human P450 2A6 selectively oxidizes APAP to 3-OH-APAP (Chen et al., 1998)
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We advise against the use of these medications for individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
doi: 10.1371/journal.pone.0039613 291 SlaninaH.KnigA.HeblingS.HauckC
