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Transport across the BBB may be facilitated by sodium-dependent transport system [76] or converting cysteine to cystine, which is subsequently exchanged with intracellular glutamate via the cystine-glutamate antiporter, and reduced back to cysteine for GSH production [115, 116]
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At the outset of each imaging session, a high-resolution anatomical dataset was obtained employing the rapid acquisition, relaxation enhancement (RARE) pulse sequence (RARE factor 8)
The degradation rate and half-life (t1/2) of the drugs were determined by measuring the decrease in area under the curve (AUC) at their retention times [2]
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