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DSIP entered the literature through delta-EEG enhancement in animal models, and the preclinical sleep work that followed examined wakefulness and sleep patterns in species including the cat (PMID 3620931)
Its been a hot topic in my practice, so it was good to read this article, and it kind of reinforced what Ive been saying, which is we dont know
In the trials, that showed up as large reductions in liver fat alongside the weight loss, which is part of why the results generated so much attention
Naltrexone/bupropion reduces weight without worsening depression
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