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Oral semaglutide shows no significant difference compared with other GLP-1 receptor agonists in the incidence of MACE, in hospitalization for heart failure, and no difference on cardiovascular death (except for Lixisenatide: HR 0.5

Non-pharmacological alternatives for diabetes and weight management will also be explored

For the full list of eligibility criteria, see Appendix S1

Tesamorelin can elevate IGF-1 into supraphysiologic ranges and increase fasting glucose or impair insulin sensitivity in some users