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Although these changes are generally not clinically significant in healthy individuals, they could pose a greater risk in populations predisposed to metabolic disorders, such as prediabetes or type 2 diabetes
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The specific radiopharmaceuticals used to examine different aspects of the BBB are explained below and summarized in Figure 4
It first decreased the expression of phospho-c-Jun-N-terminal kinase 1/2 (p-JNK1/2), and the second mechanism is by increased expression of cleaved Poly (ADP-ribose) polymerase (PARP)
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