Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
Annual Review of Biochemistry
Topical bioavailability: Lower but meaningful
For that reason, an untreated pernicious anemia often leads to neurological damage, which should explain why so many patients with neurological disorders such as Alzheimer, multiple sclerosis, peripheral neuropathy, and Bells Palsy, benefit from B12 shots
Long-Lasting Effects : Some people may only need B12 injections periodicallytypically every few weeks or monthsdepending on their health needs and doctors recommendations