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Liraglutide not only blocks insulin receptor and synaptic loss in the brain but also reverses memory impairment induced by AD-associated A oligomers, suggesting that GLP-1R activation may be used to protect brain insulin receptors and synapses in AD ( 3.2 Neuroinflammation AD and DM are significantly associated with neuroinflammatory mechanisms

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Discordance between randomised controlled trials and observational studies