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Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)
Instead, it induces alterations in protein expression patterns associated with cell-cell interactions and cellular movement (Delbaz et al., 2020), suggesting that the trigeminal nerve may also serve as an alternative pathway for the bacterium to reach the CNS from the nasal cavity
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doi:10.1126/science.abl4784
EMPA-REG OUTCOME: the Nephrologists Point of View
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