Jain AB, Kanters S, Khurana R, Kissock J, Severin N, Stafford S
To address this, future work will include pathway-level validation in gastric tissues and complementary epithelial models, specifically assessing NF-B (p65 nuclear translocation and IB phosphorylation), Nrf2 (nuclear localization and canonical targets such as HO-1 and NQO1), and TGF-/Smad (phosphorylated Smad2/3 and Smad7), alongside pharmacologic inhibition and activation experiments to test necessity and sufficiency
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Exercise, sleep, and nutrition remain indispensable for preserving metabolic health and preventing the chronic energy deficits that likely underlie dementia and Alzheimers disease
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