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The most successful treatments currently available include glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), exemplified by semaglutide (approved in 2017, $19.9 billion sales in 2023) 3 and tirzepatide (approved in 2022, $5.3 billion sales in 2023) 4
doi: 10.1038/nature16460 56 SugimotoKOgawaAMizoguchiEShimomuraYAndohABhanAKet al
Figure 1 4 Overview of the GLP-1 mechanism GLP-1 is an incretin hormone composed of 3031 amino acids, produced by post-translational processing of proglucagon and secreted by intestinal L-cells in response to nutritional and inflammatory stimuli, as well as by neurons in the brainstem
The American journal of clinical nutrition, 87(5), 1558S1561S
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