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"I was very comfortable with peptides as a potential medicine." To make the GLP-1 hormone "long-acting" her team found a way to attach a fatty acid to the molecule
Patients with consistent morning routines may find it easier to remember daily injections before breakfast, while those with variable morning schedules might prefer evening dosing
Temperature excursions during shipping or at-home storage denature the molecule entirely
In the last step, CPT II enzyme activity converts acylcarnitine back to acyl-CoA's, which undergoes -oxidation, which involves dehydrogenation, hydration, another dehydrogenation, and thiolytic cleavage
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