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Biosimilar development is the medium-term democratization opportunity Biocon Biologics, Samsung Bioepis, and other biosimilar developers are advancing semaglutide biosimilar programs that, upon patent expiry, could reduce drug costs by 70-85% and dramatically expand patient access in both developed markets with coverage barriers and developing markets with affordability constraints

Both methylmalonic acid semialdehydes are converted to propionyl-CoA via the actions of aldehyde dehydrogenase 6 family member A1 (encoded by the ALDH6A1 gene)

Over 68 weeks, the semaglutide arm achieved a mean weight loss of 14,9% compared to 2,4% for placebo

Genc H, Uzun H, Benian A, et al

Short-term fluctuations may also reflect hydration, food intake and digestive contents rather than changes in body fat