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doi.org/10.3390/ijms19071987 Seiwerth, S., et al

Although vitamin B12 deficiencies are rare in the U.S., certain medications and health conditions such as pernicious anemia can affect the absorption of vitamin B12 and contribute to a deficiency

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Loss of sterility or dosing accuracy potency declines often without visible change (colour change or cloudiness may be late indicators)

This makes it particularly valuable for patients whose skin sensitivity limits their use of more aggressive actives like retinoids