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In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide

This has been demonstrated in human peripheral blood mononuclear cells, where exenatide blocked NF-kB binding to DNA and downregulated both TNF and IL-1 beta expression

doi: 10.1210/endrev/bnaa032, 98 MerchenthalerI.LaneM.ShughrueP

Kitakata H, Endo J, Matsushima H, Yamamoto S, Ikura H, Hirai A, Koh S, Ichihara G, Hiraide T, Moriyama H, Shirakawa K

The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]