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These are the administration of insulin itself to potentiate the effect of chemotherapy, and administration of the insulin-lowering drug diazoxide

The mechanotherapeutic agent ketotifen has been shown to reprogram the TME by reducing tumor stiffness and increasing perfusion, thereby enhancing the delivery and efficacy of nanomedicine-based chemo-immunotherapy (61)

Methods Materials GSH, GSSG, 2-mercaptoethanol, ophthalmic acid, S -methylglutathione and yeast glutathione reductase (GR) were obtained from Sigma-Aldrich, HEDS was from Alfa Aesar, GSSCys from Toronto Research Chemicals and NADPH was from Gerbu

& Underhill, D