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Many of the solutions we need are hiding in plain sight in drugs made for other diseases
Elevated cAMP activates protein kinase A (PKA), which phosphorylates multiple targets including ion channels, transcription factors (notably CREB), and components of the insulin secretory machinery
As of the time of writing, both agents remain in clinical development and have not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)
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In addition, the impact of Asiatic acid on mitochondrial dynamics and tubular protection was negated following treatment with ML385 (Nrf2 inhibitor), indicating that AA could be a promising pharmaceutical agent for the management of DKD tubular damage
For GLP-1 therapy or anyone eating fewer meals
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