whey protein 1-2 scoops (added to smoothie, or with almond, hemp or coconut milk)
Intriguingly, in 2005, Mandal et al
MOTS-c activates AMPK by disrupting the folate cycle, specifically by inhibiting AICAR transformylase, an enzyme in the de novo purine synthesis pathway
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And I wonder whether or not the discomfort of cold, deliberate cold exposure, and the discomfort of heat might be anchoring to the same pathway