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Mounjaro was approved by the FDA in 2022 as a GIP and GLP-1 receptor agonist for improving blood sugar control in adults with type 2 diabetes, and subsequent trials went on to evaluate its effects specifically on body weight in people with obesity or overweight
It's because we're pulling 1 iodine molecule off it
The most striking symptom is its most life-threatening: an insatiable hunger known as hyperphagia that prompts caregivers to padlock cupboards and fridges, chain garbage cans, and install cameras
More recently, GLP-1 receptor agonists have been trialled in people with obesity
In a separate study, LY343794, another glucagon/GIP/GLP-1 triple receptor agonist, decreased body weight and improved glycaemic control in obese mice [97]
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