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Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)

The shift to weekly formulations began with Bydureon in 2012 and became standard by 2017

A study has shown that serine, whether derived from external sources or produced as an intermediate in glucose metabolism, can serve as a substrate for conversion into glycine by SHMT

(15) After inducing diabetic osteoporosis through a high fat diet and streptozotocin, light and scanning electron microscopy revealed evidence of bone deterioration via the upregulation of nuclear factor kappa-B ligand (RANKL) and downregulation of pro-osteogenic markers OPG and osteocalcin

The global 3D printed hip and knee implants market size is calculated at US$ 5.81 in 2024, grew to US$ 6.83 billion in 2025, and is projected to reach around US$ 28.87 billion by 2034