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Students t-test and one-way ANOVA were used for comparisons of two groups and multiple groups, respectively

AOD-9604 and GLP-1 agonists like Semaglutide or Tirzepatide work through fundamentally different mechanisms with very different efficacy profiles

This metabolic reprogramming not only supports cell proliferation but also elevates intracellular S-adenosylmethionine (SAM) levels, promoting epigenetic alterations and ultimately inducing the acquisition of NEPC characteristics ( PLK1 is highly expressed in high-grade prostate cancer and induces PHGDH degradation by phosphorylating residues Ser512, Ser513 and Ser517