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With the addition of icodec, the curve shifts to the right, indicating that there is competitive binding for albumin between semaglutide and icodec leading to more free semaglutide in the presence of icodec at all HSA concentrations owing to the relatively stronger albumin binding properties of icodec

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Additional studies have also shown that patients taking GLP-1 receptor agonists also have significantly lower rates of kidney outcomes such as macroalbuminuria or progression to end-stage kidney disease