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The Mitochondrial Signal for Systemic Health MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial derived peptide (MDP), a class of peptides encoded within the mitochondrial genome rather than the nuclear genome

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It is also noteworthy that due to the excess circulating IGFBPs in end-stage renal failure patients on hemodialysis, GH is only approximately 50% efficient in increasing bioactive IGF-I compared with healthy subjects (79)

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