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Potential side effects may include gastrointestinal symptoms such as nausea, vomiting, and constipation

NHS England rolled out tirzepatide for weight management in cohorts after NICE TA1026 in December 2024: 3 Cohort 1 (from June 2025): adults with a body mass index (BMI) of 40 or higher and at least four of five weight-related conditions (type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease)

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Body composition Two people of the same weight, height, sex, and age can have different metabolic rates if their muscle-to-fat ratio differs

Inhalation and injection are alternative routes of administration