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At the molecular level, within the ovarian follicular microenvironment, HS leads to the accumulation of reactive oxygen species (ROS), triggering oxidative stress, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and apoptosis (Amaral et al., 2020)

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Some studies have also shown the presence of GLP-1Rs in mood-related brain regions and demonstrated its powerful role in emotional processing within the CNS (Merchenthaler et al., 1999