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The most abundant miRNA in the samples was the miR-125a-3p, which has been shown to inactivate the Wnt/-catenin and NF-B pathways, and also that its downregulation correlates with tumorigenesis 70,71 this particular miRNAs load in the EVs was reduced with Cytochalasin D treatment, and increased with R5421 (Fig

Comprehensive treatment approaches combining lifestyle modifications with targeted antioxidant supplementation may provide the most effective strategy for improving erectile function, especially in cases where ED is driven by metabolic disorders and oxidative stress

Ox-LDL, oxidized low-density lipoprotein

This work has provided valuable insights into the molecular mechanisms and consequence of NLRP3s interaction with DNA