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doi:10.1016/j.clnu.2020.07.019 Wilding JPH, Batterham RL, Calanna S, et al
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[1] [4] Semaglutide activates the same GLP-1 receptors as the endogenous hormone, producing comparable physiological effects but with sustained duration
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This structural modification allows investigators to explore sustained receptor engagement and extended signaling activity, making it particularly useful for research designs that require observation over longer timeframes rather than short-acting responses
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