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516 In parallel, TGR5 activation in LSECs triggers NO production, which enhances hepatocyte sensitivity to HGF, further supporting liver regeneration

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Three weeks after AAV transduction, hepsin / mice were administered with 400 mg/kg APAP, followed by liver function biochemistry, histological, and pathological analyses

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Reaction 3: 6-Phosphogluconate + NADP Ribulose-5-Phosphate + CO + NADPH + H The second reaction involves the oxidation of 6-phosphogluconate, which results in the production of NADPH, carbon dioxide (CO), and ribulose-5-phosphate