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Furthermore, endocan could serve as an indicator for monitoring the response to treatment in patients with T2DM and periodontal disease, since the alteration of its levels is associated with the inflammatory state and glycemic control in individuals with these pathologies ( On the other hand, a hallmark of metabolic disorders, particularly T2DM, is the abnormal activation of both the innate and adaptive immune systems, through the recruitment of immune cells in the affected tissues, even in the absence of external pathogens or antigens (Zhou et al., 2018)

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