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The rationale is mechanistic stratification: each compound operates through a distinct molecular pathway, so research designs incorporating the full stack can probe parallel mechanisms in the same model system without confounding overlap

Unknown Cancer Risks: Modulating the immune system could potentially affect cancer surveillance mechanisms

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GLUT1 knockout (KO) T cells fail to proliferate in response to immunization with an experimental antigen or in vitro stimulation ( neg CD8 + T cells proliferated to a similar extent and expressed equal levels of granzyme B as their wild type counterparts following stimulation

10.3389/fphar.2022.995597 27 Malka-MarkovitzA.Camara Dit PintoS.CherkaouiM.LevineS