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In a public advisory on Wednesday, Health Canada said that as interest grows in GLP-1 products for weight loss, "some people may turn to unauthorized or counterfeit products, which could pose serious health risks because they have not been assessed by Health Canada for safety, effectiveness, or quality." The versions of the medications authorized for use in Canada are semaglutide (Ozempic and Wegovy injections and Rybelsus oral tablets) and tirzepatide (Mounjaro and Zepbound injections)
Am J Kidney Dis 59(4):513522
A related possibility is that some hindbrain neurons express both the estrogen receptor and GLP1R, and that activation of the former (by estrogen) amplifies signal transduction of the latter (by a GLP1R agonist)
Robert Kushner: GLP-1 appears to be a strong enough regulator, dealing with the appetite dysregulation, to really harmonize my understanding harmonize all these other factors you're talking about
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