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Whether this decline is a cause or consequence of aging and disease remains an active area of research
10.3390/antiox14010072 35 ChangB.SuY.LiT.ZhengY.YangR.LuH.et al (2024)
Young males displayed also higher NADP + /NADPH ratio in frozen blood compared to age-matched females, while NADH and GSSG were higher and GSH/GSSG ratio lower in 31-40 years old males compared to females (Supplementary figure 2i-s)
The pathological increase in NADPH oxidase-mediated superoxide (O) and peroxide production from inflammatory phagocytic cells in the course of this inflammatory reaction acts as source of oxidative stress
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