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The presence of a significant amount of CoQ 10 H 2 in cell membranes, along with enzymes capable of reducing oxidized CoQ 10 back to CoQ 10 H 2 (i.e., NAD(P)H oxidoreductases), supports the idea that CoQ 10 H 2 is an important cellular antioxidant (4)
Reticulophagy is known to migrate ER stress and reestablish ER homeostasis by eliminating damaged ER fragments through the autophagy-lysosome pathway
These combinations target complementary pathways and may provide synergistic metabolic benefits
The approval number is (467:10/2022)
Materials and methods Ovarian tumour cell lines A2780 and cisplatin-resistant derivative A2780DPP cells were obtained from ATCC (LGC Standards, Teddington, UK), via Cancer Research UK Cell Services
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