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Quick Answer: GLP-1 medications may help reduce joint pain primarily through significant weight loss that decreases mechanical stress on weight-bearing joints, though they are not FDA-approved for this purpose

In contrast, the therapeutic reduction of these bile acids by SE lost statistical significance after the same adjustment, indicating that this normalization is tightly coupled with SE-induced weight loss (Supplementary Table 1)

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Having a plan before stopping including dietary changes, exercise routines, and possible alternatives is crucial for minimizing negative effects