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The intracellular fluorescence intensity of the Dil was quantified using the PerkinElmer Operetta CLS imaging system
Safety outcomes were hospitalization for diabetic ketoacidosis (DKA), hospitalization for severe hypoglycemia and gastrointestinal events (composite of biliary disease, pancreatitis, bowel obstruction or gastroparesis)
Poor infrastructure, political unrest, economic challenges, or other barriers to patient safety follow-up can further hinder access for these patients, and lead managed access programs that do exist in these areas to be withdrawn or suspended unexpectedly [46]
Based on the primary analysis, mean change in the KCCQ-CSS was 16.6 points with semaglutide and 8.7 points with placebo (estimated difference, 7.8 points
J Rheol
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