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Other next-generation agents, such as IPN60090 (IACS-6274), have demonstrated early signs of clinical activity and effective GLS1 inhibition in Phase I studies, with ongoing trials exploring combinations (e.g., with bevacizumab and paclitaxel)
[124] The US Justice Department said the criminal fine of $515 million was the largest ever in a healthcare case and the largest criminal fine for an individual corporation ever imposed in a US criminal prosecution of any kind
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