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Many topical GHK-Cu products have been studied in controlled clinical trials for skin applications, and the evidence in this domain is more developed than for systemic applications

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Subsequently, we evaluated the levels of two crucial APAP-metabolizing enzymes, CYP2E1 and CYP1A2, revealing no significant differences in the protein expression levels and activities of CYP1A2 between hepsin / and wild-type mice either before or after APAP administration (Fig