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(D) Bar graphs and dots summarize the number of -end (+) cells from DT-injected iDTR mice (black, n =4) and DT-injected iDTR:: Pomc -Cre mice (red, n =3)

They are important in the metabolism of lipids and enables the production of cell membranes and protective covers of nerves

Endotoxin matters for the assay types described above because bacterial LPS independently activates NF-B signaling, which would confound the inflammatory-pathway readouts KPV is studied in