Fibrogenesis Tissue Repair 1 (1), 6
Is Mounjaro (tirzepatide) safe for weight loss in a patient with liver cirrhosis and esophageal varices?
Participants were randomized to receive retatrutide at doses of 1, 4, 8, or 12 mg weekly, or placebo, for 48 weeks
1 Indications And Usage ZEPBOUND is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of: 30 kg/m 2 or greater (obesity) or 27 kg/m 2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea, or cardiovascular disease)
A 2022 analysis in Diabetes, Obesity and Metabolism extended this observation to a 120-week follow-up, showing that people who stopped semaglutide returned toward their original weight trajectories within one year [4]