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Subsequent studies in the journals PNAS and JAMA Network Open the latter of which was conducted using data from the Framingham Heart Study at BU found links between higher body mass index and increased mortality risk, including the cumulative effects of weight status over multiple decades

Withdrawal symptoms can include Increased appetite Decreased satiety Elevated blood sugar levels Weight gain Elevated blood pressure and other cardiovascular changes A study from a 2022 clinical trial that tested semaglutide treatment for weight loss found that participants had regained about two-thirds of their initial weight loss on average, and many patients also experienced raised blood pressure levels

GLP-1s work by targeting the underlying biology of appetite and metabolism