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The absence of GLP1R is in agreement with the results of another immunohistochemistry study, 24 an autoradiography study, 2 and of an mRNA study, 11 but is in conflict with the study by Gier et al 25 showing GLP1R in ducts by immunohistochemistry
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In the SUSTAIN clinical trial program evaluating subcutaneous semaglutide for type 2 diabetes, once-weekly dosing (0.5 mg or 1.0 mg) reduced HbA1c by 1.5% to 1.8% from baseline, with superior glycemic control compared to specific comparators in head-to-head trials (SUSTAIN-7 vs dulaglutide
Additionally, genes that increase fat burning in the body were activated indicating a better metabolic profile
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